| Abstract |
Objective To explore the influence on the scores of HAMD, HAMA, MADS and safety for the patients with depression by citalopram combine with chinese traditional medicine. Methods 78 cases of patients with depression were randomly divided into experiment group and control group, the experiment group were treated by citalopram combine with chinese traditional medicine, the control group were treated by citalopram. The clinical effects, the scores of HAMD, HAMA, MADS, the levels of serum cortisol, PFP, NE, the safety were observed. Results The total effective rate for the experiment group(89.74%) were higher than the control group(69.23%)(P＜0.05); The scores of HAMD, HAMA, MADS for the experiment group after treatment were lower than before treatment and the control group(P＜0.05); The scores of HAMD, HAMA, MADS for the control group after treatment were lower than before treatment(P＜0.05); The levels of serum cortisol, NE for the experiment group after treatment were lower than before treatment and the control group(P＜0.05); The levels of serum cortisol, NE for the control group after treatment were lower than before treatment(P＜0.05); There had no significant difference on the levels of PFP-5-HT before and after treatment(P＞0.05); The levels of PFP-5-HT for the experiment group after treatment were lower than the control group(P＜0.05); The levels of PFP-5-HT for the control group after treatment were higher than before treatment(P＜0.05); The adverse reactions for the experiment group(28.21%) were lower than the control group(51.28%)(P＜0.05). Conclusion It has good clinical effects for the patients with depression by citalopram combine with chinese traditional medicine, it has low scores of HAMD, HAMA, MADS, with good levels of serum cortisol, PFP, NE, good safety, it has high values of clinical application.
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