International Journal of Clinical Research

Objective To investigate the safety and clinical efficacy of amiodarone therapy in patients with acute heart failure complicated by arrhythmia. Methods The study was conducted from January 2025, with a total of 100 cases collected, all of whom were patients with acute heart failure complicated by arrhythmia. The study concluded in January 2026. All patients were divided into groups based on different treatment modalities: 50 patients receiving conventional treatment formed the control group, while the remaining patients receiving additional amiodarone therapy formed the observation group. The cardiac function indices, blood pressure and heart rate control, incidence of adverse reactions, and therapeutic outcomes were compared between the two groups. Results After treatment, the observation group demonstrated superior cardiac function indices, better blood pressure and heart rate control (P<0.05). The incidence of adverse reactions was significantly lower in the observation group, and the therapeutic outcomes were markedly superior (P<0.05). Conclusion Amiodarone therapy significantly improves cardiac function indices, blood pressure, and heart rate control in patients with acute heart failure complicated by arrhythmia. Additionally, it exhibits superior safety and therapeutic efficacy, making it an effective medication that meets the treatment requirements for these patients.

Acute heart failure; Arrhythmia; Amiodarone; Safety; Clinical efficacy