International Journal of Clinical Research

Objective To explore the analysis of drug sensitivity test results of multidrug-resistant Pseudomonas aeruginosa and its guiding significance for clinical medication. Methods Collect and organize medical records of 1089 patients diagnosed with lower respiratory tract infections and positive for drug-resistant Pseudomonas aeruginosa in sputum culture from January 2021 to December 2024 in the hospital. Sort out the results of K-B method drug sensitivity test and implement in-depth analysis. Results The proportion of multidrug-resistant strains in 1089 strains of drug-resistant Pseudomonas aeruginosa showed an increasing trend year by year. The resistance rate of Pseudomonas aeruginosa to commonly used antibiotics such as compound sulfamethoxazole SXT, nitrofurantoin NIT, ampicillin/sulbactam SAM, ceftriaxone CRO, and ampicillin AMP is at a high level. Among 1089 strains of drug-resistant Pseudomonas aeruginosa, the proportion of multidrug-resistant strains showed an increasing trend year by year, with higher incidence in patients with chronic obstructive pulmonary disease, bronchiectasis, and ventilator-associated pneumonia. Conclusion At present, multidrug resistance is more prominent and needs to be given sufficient attention. Scientific and reasonable combination therapy should be applied in the clinical medication process to ensure the targeted and effective treatment.

Multidrug resistant Pseudomonas aeruginosa; Drug susceptibility testing; Clinical medication