认知训练对早期阿尔茨海默病患者的影响

The Effects of Cognitive Training on activities of daily living and cerebral blood flow of early Alzheimer disease patients

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DOI
刊名
Journal of International Psychiatry
年,卷(期) 2016, 43(5)
作者
作者单位

江苏镇江市精神卫生中心老年精神科 ;
江苏大学附属医院神经内科 ;
江苏镇江市信缘康护理院 ;

摘要
【摘要】目的:探讨认知训练对早期阿尔茨海默病患者日常生活能力及脑血流量的影响。方法:选取120例早期阿尔茨海默病患者为研究对象,采用随机数字表将上述患者随机分为研究组和对照组,每组60例。对照组仅接受药物治疗,而研究组在接受药物治疗的同时进行认知训练,两组的治疗周期为12周。治疗结束后,采用简明精神状态量表(MMSE)、日常生活能力量表(ADL)评估两组患者的认知功能和日常生活能力,并用动脉自旋标记核磁共振(ASL-MRI技术)测量其脑血流情况。结果:①治疗后研究组患者的MMSE评分、ADL评分分别为28.7±1.5和20.6±1.6,与对照组相比分数有显著变化,且差异有统计学意义(P<0.05);②治疗后研究组患者的双侧额叶皮质及皮质下、双侧颞叶皮质及皮质下的脑血流量分别为65.6±0.4和63.2±3.3,与对照组相比脑血流量有显著变化,且差异有统计学意义(P<0.05)。结论:药物结合认知训练可以改善早期阿尔茨海默病患者的日常生活能力及脑血流量。
Abstract
【Abstract】Objective :To investigate the effects of cognitive training on activities of daily living and cerebral blood flow of early Alzheimer disease patients. Methods:120 patients with early Alzheimer disease patients were divided into the experimental group with cognitive training add drug therapy and the control group with drug therapy,the two groups’treatment were 12 weeks. After treatment, taking MMSE,ADL to assess cognitive function and activities of daily living ,and taking ASL-MRI to measure cerebral blood flow. Results:①The MMSE and ADL scores were 28.7±1.5 and 20.6±1.6 in the study group, there had significant changes compared with control group(P < 0.05);②The bilateral frontal cortex and subcortical, bilateral temporal lobe cortex and subcortical cerebral blood flow were 65.6±0.4 and 63.2±3.3, there had significant changes compared with control group(P < 0.05).Conclusion Cognitive training add drug therapy can improve the activities of daily living and cerebral blood flow of early Alzheimer disease patients.
关键词
【关键词】认知训练;阿尔茨海默病;日常生活能力;脑血流量
KeyWord
【Key words】Cognitive training ; Alzheimer disease; Activities of daily living; Cerebral blood flow
基金项目
页码 817-819
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张长春*,徐心耕,汪周兵,唐小军,朱俊. 认知训练对早期阿尔茨海默病患者的影响 [J]. 国际精神病学杂志. 2016; 43; (5). 817 - 819.

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