Journal of International Psychiatry

Objective To explore the influence of sleep disturbance (SD) on quality of life (QOL) in patients with major depressive disorder (MDD). Methods This was a cross-sectional study including two steps. First, the patients with mood disorders were screened with Hospital Anxiety and Depression Scale (HADS), those with a total HADS scores ≥8 were interviewed according to DSM-IV, patients diagnosed MDD were further assessed for their sleep quality, severity of symptom, social support, personality characteristic and QOL. 667 patients were diagnosed with MDD. The severity of depression, social support, personality characteristics, sleep quality and QOL of these subjects were assessed with relevant scales. Results 454 participants (68.07%) were classified into the SD group defined by Pittsburgh Sleep Quality Index (PSQI) total score ≥7, and compared to patients without SD, those with SD scored lower in physical and psychological QOL domains. SD remained significantly negative correlation with poor QOL according to multiple linear regression analyses. Conclusion SD may be one of the risk factors of poor QOL in patients with MDD.

Major depressive disorder; Sleep disturbance; Quality of life