心境稳定剂合并右前额皮质rTMS治疗双相障碍躁狂发作患者的疗效研究
Clinical efficacy of mood stabilizers and right prefrontal cortex rTMS in treatment of patients with bipolar disorder
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2017, 44(6) |
| 作者 |
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| 作者单位 |
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| 摘要 |
探讨心境稳定剂丙戊酸联合右侧前额叶皮质重复经颅磁刺激（rTMS）治疗双相障碍躁狂发作的临床效果。方法 选取2014年5月～2016年5月本院收治的100例双相障碍躁狂发作患者采用随机数字表法分为联合组和药物组各50例，两组患者均给予丙戊酸进行基础治疗，联合组同时给予rTMS刺激治疗，连续治疗14 d（1次/d），观察两组的治疗效果差异。结果 治疗前，两组患者的BRMS、CGI-BP评分差异无统计学意义（P>0.05）；治疗7d、14d后，联合组的BRMS、CGI-BP评分均显著的低于药物组患者，差异具有统计学意义（P<0.05）。结论 丙戊酸联合rTMS治疗双相障碍躁狂发作具有较好的临床效果及安全性。
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| Abstract |
【Abstract】Objective To investigate the clinical efficacy of mood stabilizers and right prefrontal cortex rTMS in treatment of patients with bipolar disorder. Methods 100 patients with bipolar disorder in our hospital between May 2014 and May 2016 were randomly divided into combination group and drugl group with each 50 cases. Two groups of patients were treated with valproic acid basic treatment. The patients in combination group were given rTMS stimulation therapy with continuous treatment for 14 d (1 times/d). The clinical efficacy was observed before and after treapy and was compared between two groups. Results Before treatment, the BRMS, CGI-BP scores of two groups of patients showed no significant difference (P>0.05).After treatment 7d, 14d, the BRMS and CGI-BP scores of combination group were significantly lower than the drug group of patients and the difference were statistically significant (P<0.05). Conclusion Mood stabilizers and right prefrontal cortex rTMS in treatment of patients with bipolar disorder can get good effect and low rate of adverse reactions.
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| 关键词 |
心境稳定剂；丙戊酸；右侧前额叶皮质重复经颅磁刺激；双相障碍躁狂发作
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| KeyWord |
Mood stabilizers; valproic acid; right prefrontal repetitive transcranial magnetic stimulation; bipolar mania
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| 基金项目 |
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| 页码 |
1004-1007 |
苏海陵*.
心境稳定剂合并右前额皮质rTMS治疗双相障碍躁狂发作患者的疗效研究 [J].
国际精神病学杂志.
2017; 44; (6).
1004 - 1007.