International Journal of Clinical Research

This paper discusses the connection between epigenetic modifications during embryonic development and the occurrence of congenital malformations, and evaluates their value in early screening and prevention. Comprehensively analyze the dynamic change processes such as DNA methylation, histone modification and non-coding RNA during the key development period of embryos, and evaluate the predictive effect of deformity risk by combining the influence of environmental factors and maternal physiological status. Epigenetic abnormalities are closely related to neural tube defects, cardiovascular malformations and cleft lip and palate. High-throughput epigenomics analysis can achieve early risk identification and multi-omics integration, improving the accuracy of prediction. Intervention strategies mainly based on epigenetics have demonstrated potential preventive and therapeutic effects. Embryonic epigenetic modifications play a significant regulatory role in the occurrence of congenital malformations. Early marker screening and individualized intervention can provide a theoretical basis for clinical prevention and treatment, and lay a foundation for accurate prenatal diagnosis and risk management.

Embryonic development; Epigenetic modification; Congenital malformation; Early screening