International Journal of Clinical Research

Objective To investigate the predictive value of the change of disturbance coefficient in non-invasive cerebral resist monitoring technology for increased hemorrhage in patients with brain trauma, and to determine its optimal predictive cutoff value. Methods A retrospective analysis was conducted on the clinical data of 67 patients with brain trauma admitted to the Department of Neurosurgery of our hospital (a tertiary Class A hospital) from January 2022 to October 024 and monitored by a non-invasive cerebral edema dynamic monitor (BORN-BE series). Among them, 12 patients who had reble were observed, and the amplitude of the change of disturbance coefficient before and after rebleeding was analyzed. The receiver operating characteristic (ROC) curve was applied to determine the optimal coefficient cutoff value for predicting rebleeding; the correlation between the disturbance coefficient and the Glasgow Coma Scale (GCS), the Glasgow Outcome Scale (GOS) and the effect of hematoma evacuation surgery on the disturbance coefficient were also analyzed. Results The disturbance coefficient of 12 rebleeding patients increased by an average of 8 units at the time of rebleeding compared to before bleeding (P < 0.05); ROC curve analysis showed that the optimal cutoff value of the disturbance coefficient predicting rebleeding was 141.5 (AUC = 0.89, P < 0.001), with a sensitivity of 8% and a specificity of 92%; the disturbance coefficient was significantly positively correlated with the GCS score at admission (r = 0.765, P <0.05), and significantly negatively correlated with the GOS score at discharge (r = -0.532, P < 0.05); among37 patients who underwent hematoma evacuation surgery, the disturbance coefficient decreased by an average of 17.3 units after surgery compared to before surgery (P < 005). Conclusion The change of disturbance coefficient in non-invasive cerebral resistive monitoring technology is an effective predictive index for rebleeding in patients with brain, and an increase of ≥18 or an absolute value >141.5 can be used as an important threshold to indicate rebleeding, which requires timely imaging and clinical intervention. This technology has important clinical value for improving the prognosis of patients with brain trauma.

Bioimpedance; Disturbance coefficient; Traumatic brain injury; Rebleeding; Early warning; Threshold