International Journal of Clinical Research

Objective This study aims to conduct an in-depth analysis of the clinical efficacy and safety of Traditional Chinese Medicine (TCM) ultrasonic-guided drug delivery device in treating childhood tic disorder (TD) co-occurring with attention deficit hyperactivity disorder (ADHD), providing theoretical and practical references for clinical research. Methods The study period was set from September 2023 to September 2024. The sample was drawn from hospitalized children with TD co-occurring with ADHD (all meeting DSM-5 diagnostic criteria), totaling 70 cases (all receiving TCM ultrasonic-guided drug delivery device treatment). The herbal formula was formulated based on the principles of "harmonizing liver and calming wind" and "calming the mind and soothing the spirit," administered through transdermal drug delivery to acupoints including Baihui, Sishencong, Fengchi, Taichong, and Neiguan. Intervention duration: 3 sessions per week, with 4 weeks per course, totaling 8 weeks. Data collection and analysis were performed using YGTSS scores, SNAP-IV scores, total effective rate, and adverse reactions as evaluation indicators. Results Statistical analysis revealed an overall effective rate of 87.14% in children, showing significant improvement compared to pre-treatment levels (P<0.05). Conclusion The application of TCM drug delivery devices can effectively alleviate tic symptoms, attention deficits, and hyperactive impulsive behaviors in children with TD co-occurring with ADHD. With fewer adverse reactions, this non-invasive treatment method is particularly suitable for pediatric clinical use. The findings are recommended for clinical adoption.

Traditional Chinese medicine ultrasound-guided drug delivery device; Childhood tic disorder; Attention deficit hyperactivity disorder; Effectiveness