International Journal of Clinical Research

Objective To investigate the safety and efficacy of dexmedetomidine and chloral hydrate combined with dexmedetomidine for pediatric sedation. Methods This study selected 160 children admitted to our hospital who met the American Society of Anesthesiologists (ASA) classification standards (Class I and II) and required pre-procedural sedation. Using a random number table method, they were evenly divided into Group A (80 cases, receiving intranasal dexmedetomidine) and Group B (80 cases, receiving rectal chloral hydrate combined with intranasal dexmedetomidine). The intervention effects of both groups were compared and analyzed. Results In terms of sedation efficacy and efficiency, Group B demonstrated significantly shorter onset time and higher sedation success rate compared to Group A (P < 0.05). Regarding hemodynamic stability, there were no statistically significant differences between the two groups in mean arterial pressure, heart rate, respiratory rate, and oxygen saturation before administration, after sedation, and upon awakening (P > 0.05). Conclusion The combination of rectal chloral hydrate and intranasal dexmedetomidine in pediatric sedation significantly reduces the onset time and improves the success rate of sedation.

Dexmedetomidine; Chloral hydrate; Pediatrics; Outpatient sedation