International Journal of Clinical Research

Objective To explore the related factors of recurrence in patients with hyperthyroidism after drug withdrawal in the early stage of pregnancy and its impact on pregnancy outcomes. Methods A total of 94 patients with hyperthyroidism who discontinued medication in the early stage of pregnancy in our hospital were selected from June 2024 to June 2025. According to the recurrence situation of the patients, they were divided into the recurrence group (36 cases) and the non-recurrence group (58 cases). A retrospective analysis was conducted on the related factors of recurrence and their impact on pregnancy outcomes. Results Factors such as age, duration of hyperthyroidism, thyroid function indicators, thyroid autoantibodies, and family history all have an impact on the recurrence of hyperthyroidism patients after drug withdrawal in the early stage of pregnancy. Meanwhile, the incidence of adverse pregnancy outcomes in the recurrence group was higher than that in the non-recurrence group, and the difference was statistically significant (P < 0.05). Conclusion For the recurrence problem of hyperthyroidism patients after drug withdrawal in the early stage of pregnancy, individualized intervention strategies should be formulated based on high-risk factors to control the recurrence problem and improve pregnancy outcomes.

Hyperthyroidism; Discontinuing medication in the early stage of pregnancy; Recurrence; Relevant factors; Pregnancy outcome