International Journal of Clinical Research

Objective To explore the impact of optimizing dialysis timing and strengthening blood glucose control strategies on the clinical efficacy of patients with chronic glomerulonephritis complicated with diabetes. Methods Sixty patients with chronic glomerulonephritis complicated with diabetes mellitus admitted to our hospital from March 2023 to March 2024 were selected and divided into two groups by random number table method. In the control group, maintenance hemodialysis was initiated when the estimated glomerular filtration rate (eGFR) was ≤10 mL/ (min•1.73m²), combined with conventional blood glucose control. In the observation group, maintenance hemodialysis was initiated when the eGFR was 12-15 mL/ (min•1.73m²), and intensive blood glucose control was adopted. The renal function indicators, blood glucose control indicators and the occurrence of complications were compared between the two groups. Results After 12 months of treatment, the levels of Scr, BUN and UA in the observation group were all lower than those in the control group, and the level of eGFR was higher than that in the control group. After 12 months of treatment, the fasting blood glucose, 2-hour postprandial blood glucose and HbA1c levels in the observation group were all better than those in the control group. The total incidence rate of the observation group was lower than that of the control group (P < 0.05). Conclusion For patients with chronic glomerulonephritis complicated with diabetes, initiating dialysis at eGFR 12-15 mL/ (min•1.73m²) and combining it with intensive blood glucose control can improve renal function, enhance the effect of blood glucose control, reduce complications, and thereby improve the quality of life, which has clinical promotion value.

Chronic glomerulonephritis; Diabetes; Timing of dialysis; Blood sugar control; Renal function; Complications