International Journal of Clinical Research

Objective To analyze the effect of nicardipine and nifedipine in postpartum hypertensive emergencies with severe preeclampsia. Methods A total of 114 patients with severe preeclampsia and postpartum hypertensive emergencies admitted from May 2023 to January 2025 were selected. 57 cases were randomly treated with nifedipine (control group), and the other 57 cases were treated with nicardipine (observation group). Observe the effects of different therapies, compare the influences of treatment methods on sustained systolic blood pressure (SBP), diastolic blood pressure (DBP), 24-hour urine protein (24hUpro), serum NO and ET-1 levels, and record the complications of the two groups. Results After the nursing care, the therapeutic effect rate of the observation group was higher than that of the control group, with a significant difference (P<0.05). Comparison of various treatment indicators between groups before nursing (P >0.05); After treatment, the levels of SBP, DBP, 24hUpro and ET-1 in the observation group decreased significantly, and the serum NO level increased significantly. There was a significant difference between the groups (P<0.05). The complication rate of the observation group was lower than that of the control group (3.51% vs 19.30%), and the difference was significant (P<0.05). Conclusion Compared with nifedipine treatment, nicardipine has a significant effect in improving the hypertensive state, with enhanced efficacy and high safety. It is worthy of promotion and application in patients with this disease.

Severe preeclampsia; Postpartum hypertensive emergency; Nifedipine; Nicardipine