International Journal of Clinical Research

Objective To investigate the clinical efficacy and safety of Jiuxin Pill in treating patients with paroxysmal atrial fibrillation complicated with hypertension. Methods 268 patients with paroxysmal atrial fibrillation complicated with hypertension treated in our hospital from January 5, 2022 to December 18, 2023 were randomly divided into a control group (n=134) and a study group (n=134). Both groups received routine antihypertensive and antiarrhythmic treatment. The study group received additional oral Jiuxin Pill treatment, one pill twice daily, for 4 weeks. Changes in atrial fibrillation frequency, duration, 24-hour Holter monitoring atrial fibrillation burden, left atrial diameter, and high-sensitivity C-reactive protein (hs-CRP) levels before and after treatment were observed and compared between the two groups. Adverse reactions were also recorded. Results After 4 weeks of treatment, the frequency of atrial fibrillation episodes in the study group was significantly lower than that in the control group (3.21±1.04 times/week vs 5.47±1.26 times/week, P<0.001), the duration of episodes and atrial fibrillation burden were significantly reduced (P<0.01), the left atrial diameter decreased (P=0.034), and the hs-CRP level decreased more significantly (P=0.015). No significant adverse reactions occurred in either group during the treatment period; no drug-related adverse events such as worsening palpitations, dizziness, or gastrointestinal discomfort were observed, and overall tolerability was good. Conclusion Combining Jiuxin Pills with routine treatment can significantly reduce the frequency of atrial fibrillation episodes and inflammation levels in patients with paroxysmal atrial fibrillation and hypertension, improve atrial structural remodeling, and has good safety, demonstrating high clinical application value. Furthermore, the Hamilton Anxiety Rating Scale (HAMA) and Hamilton Depression Rating Scale (HAMD) scores of patients in the study group significantly decreased after treatment, suggesting that Jiuxin Pills also have a good effect in relieving anxiety and depression.

Jiuxin Pills; Paroxysmal atrial fibrillation; Hypertension; Atrial remodeling; Inflammatory factors