International Journal of Clinical Research

Objective To understand the chromosome karyotype distribution of children with abnormal growth and development in Hainan, and to explore the influence of chromosome karyotype on children’s growth and development in combination with different clinical manifestations. Methods The children aged 0-16 with abnormal growth and development from January 2020 to December 2023 in Hainan Jinyu Medical Inspection Center Co., Ltd. were taken as the research object, and the G banding of their peripheral blood samples was analyzed. Results 858 children with developmental abnormalities were screened out, including 126 cases with chromosomal abnormalities, and the detection rate of abnormal karyotype was 14.69%. There were 100 cases of chromosome polymorphism, accounting for 79.37% of abnormal karyotype. There were 16 cases of autosomal abnormality, accounting for 12.70% of the abnormal karyotype; There were 8 cases of sex chromosome abnormality, accounting for 6.35% of abnormal karyotype; The sex chromosome and autosome were abnormal at the same time in 2 cases, accounting for 1.59% of the abnormal karyotype. Conclusion Chromosome polymorphism is the main karyotype of children with dysplasia in Hainan, and sexual dysplasia, short stature and stunting are the main clinical phenotypes. It can be seen that dysplasia has an important impact on children's growth, so we should pay attention to children's growth status and see a doctor in time.

Abnormal growth and development; Children; Karyotype analysis; Detection rate