International Journal of Clinical Research

Objective To analyze the types, occurrence characteristics and related influencing factors of adverse reactions caused by the combined use of cephalosporin drugs and various Western medicines, and to provide reference for clinical rational drug use. Methods 80 patients who experienced adverse reactions after receiving cephalosporin drugs combined with Western medicines in our hospital from January 2023 to December 2024 were selected as the research subjects. A retrospective analysis method was adopted. According to different combined medication regimens, the patients were divided into the observation group (cephalosporin drugs combined with 2 or more Western medicines, 40 cases) and the control group (cephalosporin drugs combined with 1 Western medicine, 40 cases). The occurrence time, affected systems, clinical manifestations and outcomes of adverse reactions of the two groups of patients were statistically analyzed, and the correlations between adverse reactions and drug types, dosage, administration route and individual differences of patients were analyzed. Results The incidence of adverse reactions within 0-30 minutes after medication in the observation group was significantly higher than that in the control group, and the difference was statistically significant (P < 0.05); In terms of the incidence of adverse reactions in the digestive system, adverse reactions in the skin and mucous membranes, and the proportion of multiple system joint involvement, the observation group was significantly higher than the control group, and the differences between the groups were statistically significant (P < 0.05); Conclusion When cephalosporin drugs are combined with various Western medicines, the risk of adverse reactions increases. Clinically, the indications for combined medication should be strictly controlled, the medication plan should be optimized based on the individual conditions of patients, and the monitoring of adverse reactions during medication should be strengthened to ensure medication safety.

Cephalosporin drugs; Combined use of Western medicines; Adverse reactions; Rational drug use; Medication safety