International Journal of Clinical Research

Objective To analyze the efficacy and safety of olanzapine versus quetiapine in the treatment of geriatric psychiatric disorders. Methods A retrospective cohort analysis was conducted on 60 elderly psychiatric patients admitted to our hospital from January 2025 to December 2025. All patients were randomly assigned to either the olanzapine group (n=30) or the quetiapine group (n=30). Results There was no significant difference in overall clinical response rate between the two groups (P>0.05), indicating no statistical significance. Post-treatment PANSS scores in both groups showed a decline compared to baseline levels, with no statistically significant difference between groups (P>0.05). The olanzapine group exhibited a significantly higher incidence of adverse reactions than the quetiapine group (P<0.05). Conclusion Both quetiapine and olanzapine demonstrate favorable therapeutic outcomes in geriatric psychiatric disorders, significantly improving psychotic symptoms. Quetiapine exhibits superior safety profile with lower adverse reaction rates, making it more suitable for elderly patients with poor tolerance.

Olanzapine; Quetiapine; Geriatric psychosis; Therapeutic efficacy; Safety