International Journal of Clinical Research

Objective To evaluate the quality stability of the pre-decocted product of Cynanchi Paniculati Radix et Rhizoma under different storage conditions. Methods The content of paeonol, the index component, was determined by High-Performance Liquid Chromatography (HPLC), and the pH value of the samples was measured daily. Results When stored for 8 days under cool and ambient temperature conditions, the relative standard deviations (RSDs) of paeonol content were 2.35% and 2.78%, respectively (both < 3%), indicating good stability. Under refrigerated conditions, the RSD was 2.79% for the first 5 days, showing acceptable stability. However, from the 6th day onward, the paeonol content began to decrease with the RSD exceeding 3%, signifying deteriorated stability, but it remained within a controllable range. Conclusion The pre-decocted product of Cynanchi Paniculati Radix et Rhizoma exhibits good stability when stored at cool or ambient temperatures, which is verified by quality control technology research, thus ensuring its feasibility in practical application. This study provides a reference and scientific basis for the storage and quality control of pre-decocted product preparations of Chinese medicines that require “post-decoction”.

Cynanchum paniculati; Pre-decoction; Chinese medicine decoction; Quality stability; Paeonol