| Abstract |
Abstract：objective To investigate the clinical efficacy of memantine hydrochloride treatment of Parkinsons patients with dementia, and to observe its effect on improving cognitive function in patients and daily living.Methods Cut selected hospital 90 cases of Parkinsons patients with dementia according randomly divided into a control group and treatment group, 45 cases in each. Two groups of patients were treated with anti-depressants and other conventional treatment, the control group received hydrochloride donepezil in the treatment, the initial dose of 5 mg / d, 1 times / d; after treatment 7d to 10 mg / d, 1 times / d; treatment group memantine hydrochloride. Both groups were treated for 12 weeks, respectively, before treatment and after 12 weeks of treatment using the Parkinsons Disease Rating Scale (UPDRS) to evaluate the control of the disease, using the Montreal Cognitive Assessment (MoCA) evaluate cognitive function improvement; mini-mental state examination (MMSE) to evaluate its improved state of cognitive impairment; use of daily living (ADL) scale to evaluate the activities of daily living. Before and after treatment were measured in serum PAPK7, CRP and NT-3 level; statistical groups adverse reactions.Results After treatment before UPDRS score was significantly lower than treatment, MMSE, ADL and MoCA score was significantly higher than that before treatment, after treatment, UPDRS score was significantly lower than the control group, while the MMSE, ADL and MoCA score was significantly higher, P <0.05. After treatment PARK7 and CRP levels were significantly lower than before treatment, and NT-3 levels were significantly higher than before treatment, after treatment PARK7 and CRP levels were significantly lower than the control group, significantly higher levels of NT-3, P <0.05. there is no adverse reaction occurs during treatment.Conclusion Application of memantine hydrochloride to treat Parkinson dementia can significantly improve patients cognitive function and activities of daily living, and has a high safety.
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