Aging immunity: unraveling the complex nexus of diet, gut microbiome, and immune function-Immunometabolism-CSCIED科技核心评价数据库-手机版

Aging immunity: unraveling the complex nexus of diet, gut microbiome, and immune function

Aging immunity: unraveling the complex nexus of diet, gut microbiome, and immune function

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DOI	10.1097/IN9.0000000000000061
刊名	Immunometabolism IJ
年，卷(期)	2025, 7(2)
作者	Babakhani, Khatereh; Kucinskas, Amanda L.; Ye, Xiangcang; Giles, Erin D.; Sun, Yuxiang,
作者单位	Texas A&M Univ, Dept Nutr, College Stn, TX USA;
摘要	Aging is associated with immune senescence and gut dysbiosis, both of which are heavily influenced by the diet. In this review, we summarize current knowledge regarding the impact of diets high in fiber, protein, or fat, as well as different dietary components (tryptophan, omega-3 fatty acids, and galacto-oligosaccharides) on the immune system and the gut microbiome in aging. Additionally, this review discusses how aging alters tryptophan metabolism, contributing to changes in immune function and the gut microbiome. Understanding the relationship between diet, the gut microbiome, and immune function in the context of aging is critical to formulate sound dietary recommendations for older individuals, and these personalized nutritional practices will ultimately improve the health and longevity of the elderly.
Abstract	Aging is associated with immune senescence and gut dysbiosis, both of which are heavily influenced by the diet. In this review, we summarize current knowledge regarding the impact of diets high in fiber, protein, or fat, as well as different dietary components (tryptophan, omega-3 fatty acids, and galacto-oligosaccharides) on the immune system and the gut microbiome in aging. Additionally, this review discusses how aging alters tryptophan metabolism, contributing to changes in immune function and the gut microbiome. Understanding the relationship between diet, the gut microbiome, and immune function in the context of aging is critical to formulate sound dietary recommendations for older individuals, and these personalized nutritional practices will ultimately improve the health and longevity of the elderly.
关键词	aging; gut microbiome; diet; immune system; fiber; fat; protein; omega-3 fatty acids; tryptophan; galacto-oligosaccharides; high-fat diet; high-fiber diet; high-protein diet
KeyWord	aging; gut microbiome; diet; immune system; fiber; fat; protein; omega-3 fatty acids; tryptophan; galacto-oligosaccharides; high-fat diet; high-fiber diet; high-protein diet
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引用本文

Babakhani, Khatereh; Kucinskas, Amanda L.; Ye, Xiangcang; Giles, Erin D.; Sun, Yuxiang. Aging immunity: unraveling the complex nexus of diet, gut microbiome, and immune function [J]. Immunometabolism. 2025; 7; (2). - .

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