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Protein phosphatases in systemic autoimmunity

Protein phosphatases in systemic autoimmunity

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DOI	10.1097/IN9.0000000000000056
刊名	Immunometabolism IJ
年，卷(期)	2025, 7(1)
作者	Pan, Wenliang; Tsokos, Maria G.; Li, Wei; Tsokos, George C.,
作者单位	Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA;
摘要	Protein phosphatases play a critical role in maintaining immune homeostasis by regulating various signaling pathways involved in immune cell activation, differentiation, and function. In the context of systemic autoimmune diseases, dysregulation of phosphatase activity contributes to aberrant immune responses, leading to chronic inflammation and tissue damage. This review explores the role of key phosphatases from the protein serine/threonine phosphatase and protein tyrosine phosphatase families that are implicated in systemic autoimmunity. We discuss their diverse roles in immune cell subsets, the mechanisms by which their dysregulation drives autoimmune pathogenesis, and the therapeutic potential of targeting these enzymes.
Abstract	Protein phosphatases play a critical role in maintaining immune homeostasis by regulating various signaling pathways involved in immune cell activation, differentiation, and function. In the context of systemic autoimmune diseases, dysregulation of phosphatase activity contributes to aberrant immune responses, leading to chronic inflammation and tissue damage. This review explores the role of key phosphatases from the protein serine/threonine phosphatase and protein tyrosine phosphatase families that are implicated in systemic autoimmunity. We discuss their diverse roles in immune cell subsets, the mechanisms by which their dysregulation drives autoimmune pathogenesis, and the therapeutic potential of targeting these enzymes.
关键词	phosphatase; autoimmunity; PP2A; TC-PTP; SHP1; SHP2; PTPN22; DUSP22; CD45; DUSP2
KeyWord	phosphatase; autoimmunity; PP2A; TC-PTP; SHP1; SHP2; PTPN22; DUSP22; CD45; DUSP2
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引用本文

Pan, Wenliang; Tsokos, Maria G.; Li, Wei; Tsokos, George C.. Protein phosphatases in systemic autoimmunity [J]. Immunometabolism. 2025; 7; (1). - .

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