Immunometabolism at the crossroads of infection: mechanistic and systems-level perspectives from host and pathogen-Immunometabolism-CSCIED科技核心评价数据库-手机版

Immunometabolism at the crossroads of infection: mechanistic and systems-level perspectives from host and pathogen

Immunometabolism at the crossroads of infection: mechanistic and systems-level perspectives from host and pathogen

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DOI	10.1097/IN9.0000000000000069
刊名	Immunometabolism IJ
年，卷(期)	2025, 7(4)
作者	Malla, Sunayana; Shahreen, Nabia; Saha, Rajib,
作者单位	Univ Nebraska, Dept Chem Biomol Engn, Lincoln, NE 68588 USA
摘要	The emerging field of immunometabolism has underscored the central role of metabolic pathways in orchestrating immune cell function. Far from being passive background processes, metabolic activities actively regulate key immune responses. Fundamental pathways such as glycolysis, the tricarboxylic acid cycle, and oxidative phosphorylation critically shape the behavior of immune cells, influencing macrophage polarization, T cell activation, and dendritic cell function. In this review, we synthesize recent advances in immunometabolism, with a focus on the metabolic mechanisms that govern the responses of both innate and adaptive immune cells to bacterial, viral, and fungal pathogens. Drawing on experimental, computational, and integrative methodologies, we highlight how metabolic reprogramming contributes to host defense in response to infection. These findings reveal new opportunities for therapeutic intervention, suggesting that modulation of metabolic pathways could enhance immune function and improve pathogen clearance.
Abstract	The emerging field of immunometabolism has underscored the central role of metabolic pathways in orchestrating immune cell function. Far from being passive background processes, metabolic activities actively regulate key immune responses. Fundamental pathways such as glycolysis, the tricarboxylic acid cycle, and oxidative phosphorylation critically shape the behavior of immune cells, influencing macrophage polarization, T cell activation, and dendritic cell function. In this review, we synthesize recent advances in immunometabolism, with a focus on the metabolic mechanisms that govern the responses of both innate and adaptive immune cells to bacterial, viral, and fungal pathogens. Drawing on experimental, computational, and integrative methodologies, we highlight how metabolic reprogramming contributes to host defense in response to infection. These findings reveal new opportunities for therapeutic intervention, suggesting that modulation of metabolic pathways could enhance immune function and improve pathogen clearance.
关键词	innate immune cells; adaptive immune cells; virus; bacteria; fungi and pathogens
KeyWord	innate immune cells; adaptive immune cells; virus; bacteria; fungi and pathogens
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引用本文

Malla, Sunayana; Shahreen, Nabia; Saha, Rajib. Immunometabolism at the crossroads of infection: mechanistic and systems-level perspectives from host and pathogen [J]. Immunometabolism. 2025; 7; (4). - .

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