| Abstract |
【Abstract】Objective To analyze the correlation between the severity of bipolar disorder and the levels of lymphocyte subsets in patients.Method Sixty patients with bipolar disorder who were treated in our hospital from January 2023 to January 2024 were selected and divided into the mild group (n=20), the moderate group (n=26), and the severe group (n=14) according to the severity of the disease. Additionally, 68 healthy volunteers who underwent physical examinations at the physical examination center of our hospital during the same period were selected as controls. The level of lymphocyte subsets [Cell Differentiation Antigen 3+ (CD3+), cell differentiation antigen 4+ (CD4+), cell differentiation antigen 8+ (CD8+), cell differentiation antigen 45+ (CD45+)] were compared between the biphasic group and the healthy group. "CD4+/CD8+" Levels of lymphocyte subsets in patients with bipolar disorder of different degrees; Pearson correlation analysis was used to analyze the correlation between the mitochondrial level of lymphocyte subsets and the severity of bipolar disorder.Result The levels of CD3+, CD4+, CD4+/CD8+ and CD45+ in the biphasic group were all lower than those in the healthy group, while the level of CD8+ was higher than that in the healthy group (P< 0.05). The levels of CD3+, CD4+, CD4+/CD8+ and CD45+ in patients with different degrees of bipolar disorder gradually decreased, with the severe group < the moderate group < the mild group. The level of CD8+ gradually increased, with the severe group > the moderate group > the mild group (P< 0.05). Correlation analysis showed that the levels of CD3+, CD4+, CD4+/CD8+ and CD45+ were negatively correlated with the severity of bipolar disorder, while the level of CD8+ was positively correlated with the severity of bipolar disorder (P< 0.05).Conclusion The levels of lymphocyte subsets are closely related to the severity of bipolar disorder. During clinical diagnosis and treatment, a comprehensive assessment can be made in combination with the patient's immune function.
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