| Abstract |
[Abstract]Objective To explore the changes and significance of peripheral blood leukocytes, neutrophils, lymphocytes, neutrophil-lymphocyte ratio, CRP, IL-6, and ceruloplasmin levels in patients with schizophrenia, in order to provide a theoretical reference for the pathogenesis, diagnosis and treatment of related mental diseases. Methods The study included 74 patients with schizophrenia and 50 healthy controls received at the Third People's Hospital of Foshan City from January to June 2024. Patients with schizophrenia were given standard treatment. Levels of peripheral blood white blood cells, neutrophils, lymphocytes, neutrophil-to-lymphocyte ratio, CRP, IL-6, and ceruloplasmin were measured before treatment and after four weeks of treatment, as well as at admission for the control group. The trends in changes in these levels before and after treatment in patients with schizophrenia were compared. Results Before treatment, the absolute values of peripheral blood white blood cells, neutrophils, neutrophil-to-lymphocyte ratio, CRP, IL-6, and ceruloplasmin in the schizophrenia group were significantly higher than those in the healthy control group (all P<0.05); while the absolute values of lymphocytes were significantly lower than those in the healthy control group (P<0.05). After four weeks of treatment, the absolute values of peripheral blood white blood cells, neutrophils, neutrophil-to-lymphocyte ratio, and ceruloplasmin were significantly lower than before treatment (all P<0.05); while the absolute values of lymphocytes were significantly higher than in the healthy control group (P<0.05). Conclusion The levels of neutrophil-to-lymphocyte ratio, CRP, IL-6, and ceruloplasmin in peripheral blood are related to the severity of schizophrenia and can provide references for clinical diagnosis, treatment guidance, and prognosis assessment of schizophrenia.
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