| Abstract |
Objective: To explore the role of event-related potential (event-related potential，ERP) indicators in assessing anhedonia characteristics in schizophrenia patients. Methods: A total of 120 patients meeting the DSM-5 diagnostic criteria for schizophrenia, with Positive and Negative Syndrome Scale scores ≥60, were included. At baseline, the PANSS scale was used to assess the severity of the condition, and the Temporal Experience of Pleasure Scale (TEPS) was employed to evaluate the degree of anhedonia. P50, P300, mismatch negativity (MMN), and contingent negative variation (CNV) were measured. The relationship between ERP indicators and scale data was statistically analyzed using Pearson correlation analysis and stepwise linear regression analysis. Results: Pearson correlation analysis showed that the total TEPS score was positively correlated with years of education and negatively correlated with illness duration, total PANSS score, and negative symptom scale score. Anticipatory pleasure (TEPS) was positively correlated with years of education and negatively correlated with total PANSS score and negative symptom scale score. Consummatory pleasure (TEPS) was positively correlated with years of education and negatively correlated with illness duration, total PANSS score, and negative symptom scale score. Stepwise linear regression analysis revealed that total PANSS score, negative symptom score, years of education, MMN amplitude, and CNV amplitude significantly influenced the total TEPS score in schizophrenia patients (P<0.05). Years of education, negative symptom score, and MMN amplitude significantly influenced anticipatory pleasure (TEPS) (P<0.05). Total PANSS score, negative symptom score, and CNV amplitude significantly influenced consummatory pleasure (TEPS) (P<0.05). Conclusion: Different ERP indicators may be associated with different dimensions of anhedonia and can serve as objective assessment tools.
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