Journal of International Psychiatry

[Abstract] Objective To investigate the effect of risperidone dosing on markers of myocardial injury and electrocardiogram in schizophrenia. Methods A total of 116 patients with schizophrenia were selected from January 2023 to December 2024, and were randomly divided into small-dose group (60 cases) and high-dose group (56 cases) by coin-flip method, and orally administered risperidone at 3mg/d and 6mg/d, respectively. After 3 months of treatment, patients in the two groups were compared before and after treatment in terms of positive and negative syndrome scale (PANSS), serum creatine kinase (CK), creatine kinase isoenzyme (creatine kinase-MB, CK-MB) levels, and the abnormal ECG detection rate. Results All PANSS scores decreased significantly after treatment in both groups, but they were significantly lower in the high-dose group than in the small-dose group after treatment (P<0.05). Serum CK and CK-MB were significantly higher in both groups after treatment than before treatment, but they were significantly higher in the high-dose group than in the small-dose group after treatment (P<0.05). The detection rate of abnormal ECG was significantly higher in the high-dose group than in the small-dose group (P<0.05). Conclusion High-dose risperidone is more clinically effective in the treatment of schizophrenia but has higher serum myocardial injury marker levels and higher detection rates of abnormal electrocardiograms compared to small doses.

Key words Risperidone; Dosing; Schizophrenia; Markers of Myocardial Injury; Electrocardiography