| Abstract |
【Abstract】 Objective To investigate the clinical efficacy of zopiclone combined with losartan potassium-hydrochlorothiazide in the treatment of elderly non-dipper hypertensive patients with insomnia. Methods A total of 104 patients elderly non-dipper hypertensive patients with insomnia admitted in our hospital from June 2015 to June 2016 were randomly divided into observation group (n=52) and control group (n=52). The former was given zopiclone combined with losartan potassium-hydrochlorothiazide treatment,the latter was given estazolam combined with losartan potassium-hydrochlorothiazide treatment,the clinical efficacy was compared between the two groups. Results The systolic blood pressure (24hSBP, dSBP, nSBP), diastolic blood pressure (24hDBP, nDBP), heart rate (24hHR, dHR, nHR) in the observation group were significantly lower than those before treatment and better than control group, nocturnal drop rate (NDR) was increased and better than control group (P<0.05);The scores of PSQI,HAMA,HAMD and neuroendocrine hormone (Ang II, NEL, Cor, ET-1) levels in observation group after treatment were significantly lower than those before treatment and better than the control group (P<0.05);The total effective rate of insomnia in the observation group was 88.46% significantly higher 69.23% in the control group (P<0.05);The rate of blood pressure from non-dipper into dipper in observation group was 67.31%, significantly higher than 23.08% in the control group (P<0.05). Conclusion Zopiclone combined with losartan potassium-hydrochlorothiazide is effective and safe for the treatment of non-dipper hypertension with insomnia,it can significantly improve sleep quality, regulate the blood pressure patterns and decrease the heart rate.
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