Journal of International Psychiatry

【Abstract】Objective To investigate negative emotions during radiotherapy and chemotherapy for non-small cell lung cancer (NSCLC) and analyze its risk factors. Methods A total of 90 clinical data of NSCLC patients who received radiotherapy and chemotherapy in our Hospital from January 2022 to January 2024 were retrospectively collected. Negative emotions were analyzed based on the Hospital Anxiety and Depression Scale (HADS). The patients were divided into the negative emotion group (HADS≥8 points, n=38) and the non-negative emotion group (HADS < 8 points, n=52). Compare baseline data, Karnofsky Performance Status (KPS), and Social Support Rating Scale (SSRS) scores between two groups of patients. Risk factors influencing negative emotions during radiotherapy and chemotherapy in NSCLC patients through multiple factor analysis. Results Compared with the non negative emotion group, the negative emotion group had a higher proportion of patients with pathological stage IV, a higher proportion of patients with ≥ 3 adverse reactions, and lower KPS and SSRS score data (P＜0.05). Multiple factors have confirmed that pathological stage IV, grade ≥ 3 adverse reactions, and decreased KPS and SSRS scores are all risk factors for negative emotions in NSCLC patients during radiotherapy and chemotherapy (P＜0.05). Conclusion NSCLC patients often experience negative emotions during radiotherapy and chemotherapy, and pathological staging, grade ≥ 3 adverse reactions, KPS score, and SSRS score are all influencing factors of negative emotions in NSCLC patients, which should be given sufficient attention in clinical practice.

【Key words】 Non-small cell lung cancer; Chemotherapy and radiotherapy; Negative emotions; Risk factors