阿立哌唑治疗精神分裂症疗效及对执行、决策功能的影响
Efficacy of Aripiprazole in The Treatment of Schizophrenia and Its Effect on Cognitive Function and Prolactin
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| DOI |
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| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2025, 52(1) |
| 作者 |
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| 作者单位 |
安徽省荣军医院 精神科7病区
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| 摘要 |
摘要 目的：探讨阿立哌唑治疗精神分裂症(Schizophrenia, SZ)疗效及对执行、决策功能的影响。方法：观察对象为2020年3月-2024年3月98例SZ患者，抛硬币法随机分为两组，对照组服用利培酮，观察组服用阿立哌唑，比较两组患者精神症状、执行、决策功能。结果：治疗后两组SZ阴性、阳性以及一般精神病理症状评分均明显下降，执行功能评分、决策功能评分上升，（P<0.05），治疗后组间症状评分差异无统计学意义，（P＞0.05），观察组执行功能评分、决策功能评分更高，（P<0.05）。结论：相比于利培酮，阿立哌唑治疗SZ疗效相当，但执行、决策功能改善效果更佳。
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| Abstract |
[Abstract] Objective To investigate the efficacy of aripiprazole in the treatment of schizophrenia (SZ) and its effects on executive, decision function. Methods The observation subjects were 98 SZ patients from March 2020 to March 2024, which were randomly divided into two groups by coin-flip method. The control group took risperidone and the observation group took aripiprazole. Psychiatric symptoms, executive, decision function were compared between the two groups. Results SZ negative and positive as well as general psychopathological symptom scores decreased significantly and executive function score, decision function score increased in both groups after treatment (P<0.05). The difference in symptom scores between the groups after treatment was not statistically significant (P>0.05). Executive function score, and decision function score were higher in the observation group (P<0.05). Conclusion Compared to risperidone, aripiprazole has comparable efficacy in the treatment of SZ, but with better improvement in executive function, and decision function.
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| 关键词 |
关键词：阿立哌唑; 利培酮;精神分裂症;疗效; 执行功能；决策功能
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| KeyWord |
Key words Aripiprazole; Risperidone; Schizophrenia; Efficacy; executive function; decision function
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| 基金项目 |
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| 页码 |
54-56 |
陈飞飞.
阿立哌唑治疗精神分裂症疗效及对执行、决策功能的影响 [J].
国际精神病学杂志.
2025; 52; (1).
54 - 56.