Journal of International Psychiatry

[Abstract] Objective To investigate the relationship between sleep EEG parameters and cognitive functioning in major depressive disorder (MDD). Methods Ninety-two patients with MDD from January 2021 to January 2024 were selected. The Montreal cognitive assessment (MoCA) scale was used to assess the cognitive function of the patients. Sleep EEG was performed. Sleep EEG parameters were compared between patients with cognitive impairment (CI) and those without CI. To analyze the correlation between sleep EEG parameters and MoCA scores in patients with CI. Results Sixteen of 92 patients with MDD presented with CI, all of which were mild.In the sleep EEG parameters of patients with CI, the total sleep duration, sleep efficiency, and rapid eye movement period were lower than those of patients without CI, and the sleep latency, number of awakenings, and time were higher than those of patients without CI (P<0.05).In the patients with CI, the total sleep duration, sleep efficiency, and rapid eye movement period correlated positively with the MoCA scores, and the number of awakenings, and time were negatively correlated with the MoCA score were negatively correlated (P<0.05). There was no significant correlation with sleep latency (P>0.05). Conclusion Patients with MDD are prone to mild CI, and patients with CI exhibit reduced sleep duration and decreased sleep efficiency, and sleep EEG parameters have a strong correlation with cognitive function.

Key words Major Depressive Disorder; Sleep EEG Parameters; Cognitive Functioning