| Abstract |
Objective To analyze the causal relationship between immune cells and depressive disorder. Methods A comprehensive two-sample Mendelian randomization (MR) analysis was used to determine the causal relationship between immune cell characteristics and depressive disorders. Based on publicly available genetic data, we explored the causal relationship between 731 immune cell signatures and depression risk, using sensitivity analyses to validate the robustness, heterogeneity, and horizontal pleiotropy of the results. Results There was significant causal relationship between 45 immunophenotypes and the occurrence of depression, involving multiple immune cell subsets, such as B cells, cDC cells, bone marrow cells, TBNK cells, T cell maturation stage and Treg cells. Among them, several immunophenotypes were significantly positively correlated with the occurrence of depression, such as IgD-CD24-% B cells (P=0.001, OR=1.028), IgD-CD24-AC cells (P=0.039, IGD-CD24-AC cells), IGD-CD24-AC cells, IGD-CD24-AC cells, IGD-CD24-AC cells, IGD-CD24-AC cells, IGD-CD24-AC cells, IGD-CD24-AC cells. OR=1.025) and CD25 on IgD+ CD38-naive (P=0.028, OR=1.015). In addition, some phenotypes showed negative correlations, such as IgD-CD38-% lymphocytes (P=0.042, OR=0.975). Reverse MR Analysis showed that no significant causal relationship was observed between 45 immunophenotypes and depression (P > 0.05). Conclusion This study proved the close relationship between immune cells and depression through genetic means, and provided guidance for future clinical research.
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