Journal of International Psychiatry

【Abstract】 Objective To investigate the effects of different doses of succincholine chloride combined with propofol on delirium risk and stress response in patients treated with Modified Electroconvulsive Therapy (MECT). Methods 300 patients who underwent non convulsive electroconvulsive therapy in our hospital from January 2021 to October 2023 were selected and randomly divided into an observation group and a control group, with 150 cases in each group, using a random number table method. The control group was given succincholine chloride (1.0mg/kg) combined with propofol for anesthesia, and the observation group was given 1.5mg/kg succincholine chloride combined with propofol. Compare the stress response factor indicators [epinephrine (E), norepinephrine (NE), and cortisol (Cor)] between two groups of patients, and also compare the number, duration, and type of delirium occurrence. Results The E, NE, and Cor indicators in the observation group were lower than those in the control group after anesthesia, and the difference was statistically significant (P<0.05); The total incidence of delirium in the observation group was 10.67%, and the proportion of excitatory delirium was 37.50%, which was lower than that in the control group (19.33%, 72.41%), and the difference was statistically significant (P<0.05). Conclusion 1.5mg/kg succincholine chloride combined with propofol in MECT can reduce the risk of delirium and alleviate stress response.

【Key words】 Succinylcholine chloride; Propofol; Non convulsive electroconvulsive therapy; Stress response; Delirium