Journal of International Psychiatry

[Abstract] Objective To study the effect of mindfulness based cognitive therapy combined with paroxetine on patients with recurrent colorectal cancer and depression, and observe its impact on cancer pain and self compassion levels in patients.Methods 84 patients with recurrent colorectal cancer and depression admitted in our hospital from April 2021 to October 2023 were selected as the research subjects,they were divided into two groups accorded to different treatment plans.42 cases in the observation group were treated with mindfulness based cognitive therapy combined with paroxetine; 42 cases in the control group, treated with paroxetine.The treatment effects of two groups were compared,the cancer pain, self compassion and daily living activities before and after treatment were recorded.Results After intervention, the self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores of the two groups of patients significantly decreased compared with before intervention, and the SAS and SDS scores of the observation group after intervention were lower than those of the control group (P<0.05).After intervention, the numerical rating scale score of the observation group was lower than that of the control group, and the self compassion scale score was higher than that of the control group (P<0.05).After intervention, the daily living activities of the observation group was better than that of the control group,the difference was statistically significant (P<0.05).Conclusion The combination of mindfulness based cognitive therapy and paroxetine has significant effect on patients with recurrent colorectal cancer and depression,it can help to alleviate cancer pain, improve self compassion levels, and enhance daily living activities.

[Keywords] colorectal cancer; recurrence; mindfulness based cognitive therapy; paroxetine; self compassion; cancer pain