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Abstract: Objective To observe the effect of Tongqiao Huoxue capsule combined with escitalopram oxalate on neurological, cognitive function and cerebral blood flow in patients with post-stroke depression (PSD). Methods Eighty-four patients with PSD were semi-randomized into control group and observation group, 42 cases in each group. The control group was treated with escitalopram oxalate while the observation group, based on this, was treated with Tongqiao Huoxue capsule, and both groups were treated for 8 weeks. Before and after treatment, the National Institutes of Health Stroke Scale (NIHSS) was used to evaluate the neurological function of patients, the Mini-mental Examination (MMSE) and Hamilton Depression Scale (HAMD) were used to evaluate the cognitive function and relief of depression in patients, and Barthel index (BI) was used to evaluate the improvement of activities of daily living. Cerebral CT perfusion examination was performed to determine the changes of cerebral blood flow, and the adverse reactions were statistically analyzed. Results: After 8 weeks of treatment, the scores of NIHSS and HAMD decreased while scores of MESS and BI increased. Compared with those in the same group before treatment, there were significant differences (P>0.05), and the increase and decrease in observation group were more significant than those in control group (P<0.05); After 8 weeks of treatment, CBV was increased, MTT was shortened and CBF was increased. Compared with those in the same group before treatment, there were significant differences (P<0.05), and the increase and decrease in observation group were more significant than those in control group (P<0.05); There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion In the clinical treatment of patients with PSD, the application of Tongqiao Huoxue capsule combined with escitalopram oxalate can optimize the neurological and cognitive function of patients, relieve depression and improve the blood perfusion level, with safety.
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