Journal of Chemistry and Chemical Research

Ibuprofen, a commonly used non-steroidalanti-inflammatory drug (NSAID), has a huge market demand. Traditional synthesis methods are characterized by complex procedures, numerous side reactions, low raw material utilization, and significant pollution. Continuous flow chemistry technology, with its advantages of efficient mass and heat transfer, precise temperature control, and continuous production, has made a breakthrough in the green synthesis of ibuprofen. This study employs microchannel reactors to optimize key steps such as Friedel-Crafts acylation and acetalization. By adjusting parameters like concentration and temperature, the process enhances reaction efficiency and selectivity while reducing energy consumption and emissions. This process offers both economic and environmental benefits and has broad industrial application potential.

Continuous flow chemistry technology; Ibuprofen; Green synthesis process; Microchannel reactor; Reaction optimization