| Abstract |
【Abstract】Objective: To explore the efficacy of escitalopram oxalate in elderly patients with benign prostatic hyperplasia and depression.Methods: 104 elderly patients with benign prostatic hyperplasia and depression were selected as the research subjects, divided them into the research group and the control group, each group has 52 cases. Patients in the control group were treated with conventional drugs, and the research group was given escitalopram oxalate on this basis. The international prostate symptom score (IPSS), SF-36 scale and depression scale were compared between the two groups. Results: ①The IPSS scores of the two groups were lower than those before treatment (t = 17.491, 9.993, P <0.05), and the IPSS scores of the research group were lower than those of the control group (t = 3.571, p <0.05);②After treatment, the scores of anxiety, weight loss and cognitive impairment and other index scores decreased significantly in the research group compared with those before treatment (t = 11.220,2.273,4.773,5.852,9.267,7.627,9.765, both p <0.05) ; After treatment, the day and night changes in the control group, sleep disorder scores were lower than before treatment（t=3.334，1.593，p<0.05）, but there were no statistically significant differences of the other indicators score before and after treatment; After treatment, the study group scores were better than the control group (t= -10.009, -2.309, -4.347, -3.966, -7.700, -5.905, -9.909 p <0.05), the difference was statistically significant. Conclusion: Elderly benign prostatic hyperplasia with depression in patients given escitalopram oxalate drug therapy, can improve their symptoms of depression, reduce the symptom score, and can improve the quality of life of patients, the effect is significant.
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