Journal of International Psychiatry

Objective: To investigate the changes of cerebral resting amplitude of low frequency fluctuation (ALFF) in patients with post-stroke depression (PSD) and its relationship with clinical symptoms. Method: 32 patients with PSD and 35 non-PSD stroke patients were enrolled in this study. The ALFF method was used to analyze the changes of brain regions in patients with PSD during in the resting-state functional MRI. Pearson correlation was used to analyze the correlation between different brain regions and the Montgomery Depression Rating Scale (MADRS). Results: Compared with the control group, the patients with PSD had decreased ALFF in right precentral gyrus (Z=-2.737, P<0.01), left inferior frontal gyrus (Z=-2.775, P<0.01) and left supramarginal gyrus (Z=-2.338, P<0.01). The ALFF of the right precentral frontal gyrus was negatively correlated with the MADRS score (r=-0.428, P=0.015). Conclusion: The activity of multiple brain regions in PSD patients is decreased and correlated with clinical symptoms, which provides an important reference for the objective evaluation of clinical PSD.

post-stroke depression; amplitude of low frequency fluctuation; symptoms; correlation