Journal of International Psychiatry

[Abstract]: Objective：To determine the relationship between plasma concentration and clinical efficacy ,serum nerve function indexes of quetiapine in schizophrenics. Methods: A total of 95 male patients with schizophrenia in this hospital during January 2014 to December 2015 were allocated in study group，85 healthy persons at the same time were allocated in control group,then serum nerve function related indexes of these two groups were detected and compared ,and the relationship between plasma concentration and clinical efficacy ,serum nerve function related indexes of quetiapine was analyzed. Results: Nonlinear regression analysis showed that, when BPRS% reduction rate > 30%, serum concentration range of patients in the study group was 130 -360 ng·mL-1 , and dose range was 160 - 500 mg· d -1。At the 6th weekend, there was a significant statistical correlation between the serum concentration and the clinical efficacy of the patients in the study group（P<0.05）.The serum levels of NSE，S100B in study group were higher than those of control group，serum levels of BDNF was lower than those of control group( all P<0.05) ,and the difference in these indexes of study group with different stages was obvious ( all P<0.05). The quetiapine plasma concentration was closely related to Serum nerve function indexes in the study group（P<0.05）.Conclusion: The serum nerve function related indexes of male patients with schizophrenia show in abnormal status.The Serum nerve function indexes is bound up with the male schizophrenia patients. The level of serum NSE, S100B and BDNF in the patients can be adjusted by regulating the function of serum nerve, which can effectively control the clinical symptoms of patients.

[Key words]: Quetiapine; male; schizophrenia; blood drug concentration; clinical efficacy; nerve function indexes