Journal of International Psychiatry

[Abstract]： Objective: To study the association of plasma brain - derived neurotrophic factor( BDNF) , serum triglyceride and anxiety and depression symptoms in depression patients complicated with type 2 diabetes mellitus so as to provide reference for exploring the pathogeny of depression complicated with type-2 diabetes mellitus．Methods: 42 depression patients complicated with type 2 diabetes mellitus from January 2014 to August 2015 were assigned into A group, Selected the same period in our hospital 90 cases of type-2 diabetes patients as B group.Meanwhile，90 healthy subjects who visited the hospital for health examination during the same period were selected as the control C group．Plasma BDNF concentrations were measured by ELISA ,TG concentrations were measured by automatic biochemical analyzer, depression and anxiety were assessed by HAMD and HAMA. In A group，the associations between BDNF levels and TG，the degree of depression，and depression duration were further analyzed．Results: The total scores of HAMD and HAMA in A group were significant higher in the B，C group （P＜0.05）. The contents of BDNFin the A group were significant lower in the B，C group（P＜0.05）. The contents of TG in the A group were significant higher in the B，C group（P＜0.05）. The correlation analysis showed significant negative correlation between the BDNF and the total scores of HAMD and HAMA （r =-0.806，r =- 0.824，P＜0.01），the significant negative correlation between the BDNF and the TG（ r =- 0.713， P＜0.01）.Conclusions: Plasma BDNF concentrationis lower in depression patients complicated with type 2 diabetes mellitus; moreover，it is related to TG, anxiety and depression symptoms．

[Key words]：Depression; diabetes; BDNF; TG; HAMD; HAMA