Journal of International Psychiatry

Abstract: Objective: To investigate the effect of maintenance treatment with different doses of amisulpride on social function and living quality of schizophrenics at recovery stage. Methods: A total of 106 cases of schizophrenics at recovery stage were randomly divided into Observation Group and Control Group, with 53 cases in each group. Patients in Control Group were performed semi-dose of amisulpride, while those in Observation Group were performed full dose of amisulpride. After follow-up visit of 6 months, the social function, living quality and untoward effects in the two groups were compared. Results: After 6 months of follow-up visit, Observation group efficient 84.91% was significantly higher than the control group 60.38% （x2=8.022, P<0.05）; scores of indexes in social disability screening scale (SDSS) in Observation Group were significantly lower than in Control Group (P<0.05, P<0.01); scores of dimensions of Generic Quality of Life Inventory-74 (GQOLI-74) were significantly higher than in Control Group (P<0.05); the difference in dizziness and other untoward effects of the two groups had no statistically significance (39.62% vs 35.85%) (P>0.05). Conclusion: Maintenance treatment with full dose of amisulpride in treating schizophrenics at recovery stage can help to enhance social function and improve living quality of the patients.

Keywords: amisulpride; different doses; schizophrenics at recovery stage; social function; quality of life