| Abstract |
[Abstract] Objective Observe the result of analysis on brain CT of 80 cases of patients with treatment-resistant schizophrenia, understand the relationship between the changes of brain and the onset of schizophrenia, and investigate its clinical features. Methods Given 80 cases of patients with treatment-resistant schizophrenia brain CT scan in our hospital from December 2012 to December 2015. Compared them with the results of brain CT on 80 cases of normal medical examers and grouped them into the observation group and the control group respectively. Investigated the symptoms of schizophrenia of patients by Minnesota Multiphasic Personality Inventory （MMPI）. The relationship between family history, sex, character and age of patients with brain atrophy was studied by CT test. Results 45 cases of patients out of 80 cases of patients with treatment-resistant schizophrenia showed diffuse brain atrophy, included 19 cases of cortical type, 8 cases of medullary type, 15 cases of cortical and medullary type, 2 cases of cerebellar atrophy type and one case of increased nucleus density on both sides. The MMPI socres of patients all exceeded 50 at the aspect of social inward, athopia, split personality, hypomania, bigotry, hysteria, depression, hypochondriasis and their mental symptoms were serious. Meanwhile, the number of patients with brain atrophy increased with age (p<0.05). There was no significant difference in the proportion of the patients with brain atrophy in the personality such as schizoid personality, paranoid personality and outgoing personality（p>0.05）. Conclusion It is found with the brain CT scan of the patients with treatment-resistant schizophrenia that more than half of the patients show different types of brain atrophy and brain atrophy is closely related to treatment-resistant schizophrenia.
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