Journal of International Psychiatry

Abstract Objective To explore the applicative effect of blood pressure, emotional state and untoward effect in the hypertension associated with anxiety and depression patients by different treatment cycle fluoxetine. Methods 150 cases of hypertension associated with anxiety and depression patients were randomly divided into A group(50 cases), B group(50 cases) and C group(50 cases). The three groups were treated by conventional treatment + fluoxetine after admission. A group: fluoxetine 8 weeks + placebo 8 weeks; B group: fluoxetine 12 weeks + placebo 4 weeks; C group: fluoxetine 16 weeks. The applicative effects and safety were observed. Results The level of SBP and DBP after treatment for B and C group were lower than A group(P＜0.05); The level of SAS and SDS after treatment for B and C group were lower than A group(P＜0.05); The level of NE after treatment for B and C group were lower than A group(P＜0.05); The level of 5-HT after treatment for B and C group were higher than A group(P＜0.05); The level of NE after treatment for C group was lower than B group(P＜0.05); The level of 5-HT after treatment for C group was higher than B group(P＜0.05); The rate of untoward effect for A and B group were lower than C group(P＜0.05). Conclusion It can improve the blood pressure, emotional state and levels of NE, 5-HT for the hypertension associated with anxiety and depression patients by fluoxetine. The 12 weeks treatment cycle’s applicative effect is exactly and safety.

Keywords Hypertension associated; Anxiety and depression; Fluoxetine; Treatment cycle