度洛西汀联合艾司西酞普兰治疗老年躯体形式障碍疗效观察
Curative Effect Observation on Duloxetine in Combination with Escitalopram in Treating Elderly Patients with Somatoform Disorders
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2017, 44(6) |
| 作者 |
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| 作者单位 |
张家港市第四人民医院 心身科 ;
张家港市第四人民医院 精神科 ;
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| 摘要 |
摘要：目的：探讨度洛西汀联合艾司西酞普兰治疗老年躯体形式障碍的临床疗效及安全性。方法：选择120例老年躯体形式障碍患者为研究对象，采用随机数字表法分为观察组和对照组各30例，对照组给予艾司西酞普兰治疗，观察组给予度洛西汀联合艾司西酞普兰治疗，两组疗程均为6周，比较两组症状自评量表（SCL-90），采用汉密尔顿抑郁量表(HAMD)评价临床疗效，观察药物不良反应。结果：观察组躯体化、人际敏感、抑郁、焦虑等SCL-90评分均明显低于对照组（P<0.05）；观察组HAMD评分明显低于对照组（P<0.05），总有效率93.33%明显高于对照组70.00%(P<0.05)；两组药物不良反应发生率（26.67% vs 36.67%）比较差异无统计学意义（P>0.05）。结论：度洛西汀联合艾司西酞普兰治疗能有助于改善老年躯体形式障碍患者躯体化症状，提高治疗效果，且安全性值得肯定。
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| Abstract |
Abstract: Objective: To investigate the clinical efficacy and safety of duloxetine in combination with escitalopram in treating elderly patients with somatoform disorders. Methods: A total of 120 cases of elderly patients with somatoform disorders were selected as the research objects and divided into Observation Group and Control Group according to the random number table method, with 30 cases in each group. Patients in Control Group were treated by escitalopram, and patients in Observation Group were treated by duloxetine in combination with escitalopram. The course of treatment of the two groups was 6 weeks. The results of symptom checklist-90 (SCL-90) of the two groups were compared, Hamiltons Depression Scale (HAMD) was adopted to evaluate the clinical efficacy, and adverse drug reaction was observed. Results: The SCL-90 scores including somatization, interpersonal sensitivity, depression and anxiety in Observation Group were significantly lower than in Control Group (P<0.05); the HAMD score in Observation Group was significantly lower than in Control Group (P<0.05), the total effective rate was 93.33% and significantly higher than 70.00% in Control Group (P<0.05); the difference in adverse reaction rates of the two groups (26.67% vs 36.67%) had no statistical significance (P>0.05). Conclusion: Duloxetine in combination with escitalopram can help to improve the somatic symptoms of elderly patients with somatoform disorders and enhance the treatment effect, and the safety is worthy to be affirmed.
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| 关键词 |
关键词：躯体形式障碍；艾司西酞普兰；度洛西汀；治疗效果
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| KeyWord |
Key words: somatoform disorders; escitalopram; duloxetine; treatment effect
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| 基金项目 |
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| 页码 |
1012-1014 |
全传升*,潘继英.
度洛西汀联合艾司西酞普兰治疗老年躯体形式障碍疗效观察 [J].
国际精神病学杂志.
2017; 44; (6).
1012 - 1014.