Journal of International Psychiatry

【Abstract】Objective To investigate the association of 13 SNP polymorphisms with the risk of schizophrenia in ANK3. Method Case-control study in a northern Chinese Han population of 499 schizophrenia patients and 500 controls to investigate the effect of variant genotypes of 13 SNPs in ANK3 on schizophrenia risk. Results The minor allele of rs958852 in ANK3 was associated with a 0.75- fold reduction in schizophrenia risk in an allelic model. In the genetic model, rs958852 was associated with a reduced schizophrenia risk, and rs10994336, rs10994338 and rs4948418 were associated with an increased schizophrenia risk (rs10994336, OR=2.00, 95%CI: 1.01–3.94, P = 0.047; rs10994338, OR = 1.99, 95%CI: 1.01–3.93, P = 0.047; rs4948418, OR = 2.00, 95%CI: 1.01–3.94, P = 0.047). In addition, haplotype “TTC” of ANK3 was associated with a 0.73-fold reduced schizophrenia risk (95%CI: 0.54–0.99; P = 0.044). Conclusion The ANK3 gene is associated with the occurrence of schizophrenia, and the rs10994336, rs10994338, rs4948418 polymorphisms are associated with the occurrence of schizophrenia, and rs958852 is associated with a reduced incidence of schizophrenia.

【Key words】Schizophrenia; Single nucleotide polymorphism; Genetic susceptibility