Journal of International Psychiatry

【Abstract】 Objective To observe the synergistic effect of ketamine on antidepressant of escitalopram in depressive patients. Methods 82 patients with depression were selected and divided into observation group and control group according to the random number table, 42 cases in each group. The observation group was treated with ketamine combined with escitalopram, and the control group was treated with escitalopram alone. The rates of cure and efficacy after treatment of 4 weeks, the overall mental state , the isolated symptoms , the manic Symptoms before and after treatment, the total incidence of adverse reactions were compared between the two groups. Results The cure rate and effective rate of the observation group were 71.43% and 90.48%, which were higher than those of the control group (P<0.05). The BPRS score of the control group decreased from 2 h after treatment (P<0.05). The BPRS score of the control group decreased significantly from 24 h after treatment (P<0.05). The BPRS scores of the observation group at different time points after treatment were lower than those of the control group (P<0.05). There was no significant change in the scores of CADSS before and after treatment (P>0.05).The YMRS score of the observation group at 2h and 4h after treatment were higher than that before treatmentand those in control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion A single low-dose intravenous ketamine combined with escitalopram treatment of depression with synergistic effect, which is conducive to rapid antidepressant and improve the overall mental state of patients, and mild side effects, no significant separation and manic symptoms, Compared with escitalopram, adverse reactions did not increase significantly.

【Keywords】Depression; Escitalopram; Ketamine; Synergistic effect