| Abstract |
【Abstract】 Objective: To investigate the serum levels of nutritional markers in elderly patients with mild cognitive impairment (MCI) and their correlation. Methods: 120 patients with mild cognitive impairment were selected. According to the criteria of MCI, group A was a single amnion (52 cases), group B was a multiple cognition type (68 cases), and 80 healthy subjects were selected as the group C (normal control group). The medical history and blood samples of all subjects were collected, the blood nutrition marker content were measured, including serum folic acid, vitamin B12 (VitB12), Homocysteine (Hcy),Serum total cholesterol (TC),Serum triglyceride (TG), Apolipoprotein A (ApoA), Apolipoprotein B (ApoB), Prealbumin (PA). Results: ①There were significant differences in the scores of cognitive function among the three groups (all P <0.05); results of comparison of every two groups showed that, compared with group C, the memory function, language function and executive function of group A were damaged; compared with group C, every cognitive function of group B was obviously damaged. The cognitive function, executive function and visual function of group B were significantly lower than those of group A (P <0.05), there was no significant difference in memory function between the two groups. ②There were statistically difference in serum folic acid, Hcy ,TC,TG, ApoB, PA levels among the three groups (F=3.311, 6.526, 5.134, 4.795，5.022，6.172，all P<0.05), there was no significant difference in VitB12 and ApoA1between the three groups (F = 1.415, 1.212, P> 0.05); The levels of folic acid in group B were lower than those in control group (t = -4.788, P <0.05), the differences of Hcy ,TC,TG, ApoB, PA levels between any two groups were statistically significant (P<0.05). ③ Pearson correlation analysis showed that there was a negative correlation between the severity of cognitive dysfunction and folic acid and PA (r = -0.256, -0.347, P <0.05), a positive correlation between the severity of cognitive dysfunction and Hcy, TC, TG, and ApoB（r=0.405, 0.517, 0.406, 0.412，all P<0.05）, and the correlation was statistically significant. Conclusion: The levels of serum folic acid, Hcy, TC, TG, Apo, PA and other nutritional markers in elderly patients with mild functional impairment were lower than those in healthy subjects. These nutritional markers were correlated with the severity of mild functional impairment, they had some potential value in early intervention of cognitive impairment.
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