| Abstract |
【Abstract】Objective: To investigate the clinical efficacy of Paleys slow release agent in the treatment of first-episode and recurrent schizophrenia and the improvement of social function. Methods: from January 2014 to January 2016 for the first time in our hospital for treatment of 20 cases of schizophrenia patients (the first group) and the recurrence of the hospital for treatment of 20 cases of schizophrenia patients (recurrence group) as the research object, two groups of patients were treated with risperidone sustained-release agent Paley treatment. The two groups of patients were treated with Paley. Respectively in the two groups of patients before treatment, 2 weeks, 4 weeks and 8 weeks with positive and negative symptoms scale (PANSS) before and after treatment, social function (PSP score), clinical efficacy and incidence of adverse drug reactions were compared. Results: by comparison, the scores of PANSS of two groups had no significant difference (P>0.05), 2 weeks, 4 weeks and 8 weeks after treatment, the first group of patients between the scores of PANSS, positive symptoms, negative symptoms and general pathology score lower than before treatment, the difference was significant (P<0.05), And the recurrence group of patients with PANSS score, positive symptoms and general pathology scores than before treatment (P<0.05), low and negative symptoms after 2 weeks of treatment, no significant difference, but the difference in the treatment of 4 weeks was statistically significant (P<0.05); Comparison of two groups of patients with total score of PSP after 8 weeks of treatment there were significant differences before (P<0.05), there was no significant difference between the two groups (P>0.05), but the first group was higher than that in total recurrence group; the first group and recurrence group compared the clinical effective rate and adverse reaction of the total there was no significant difference between the latter and (P>0.05). Conclusion: significant efficacy of risperidone sustained-release agent Paley treatment of first-episode and recurrent schizophrenic patients with positive and negative symptoms, and has a certain degree of security, and can improve the patients social function to a certain extent, so it is worthy of clinical application.
|