幽门螺杆菌耐药基因检测在个体化根除治疗中的价值-国际内科前沿杂志-CSCIED科技核心评价数据库-手机版

幽门螺杆菌耐药基因检测在个体化根除治疗中的价值

The value of Helicobacter pylori resistance gene detection in personalized eradication therapy

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DOI	10.12208/j.ijim.20240005
刊名	国际内科前沿杂志 International Journal of Internal Medicine
年，卷(期)	2024, 5(1)
作者	张俊,
作者单位	西安医学院陕西西安
摘要	幽门螺杆菌（H. pylori）耐药性增加导致传统经验性根除治疗失败率升高，亟需精准干预策略。本文系统阐述耐药基因检测对个体化治疗的指导价值，重点解析23S rRNA、gyrA、PBP1等基因突变与克拉霉素、左氧氟沙星、阿莫西林耐药表型的关联机制。研究表明，基于基因型检测的个体化方案可显著提升根除率，较传统经验疗法更具优势，同时降低抗生素不合理使用及相关不良反应发生率。多重耐药菌株的精准识别依赖于实时荧光PCR、基因测序等技术的临床应用，其快速性和特异性为优化治疗方案提供技术保障。研究进一步指出，整合区域性耐药流行病学数据、建立标准化检测体系是提高治疗成功率的关键，标志着幽门螺杆菌感染治疗向精准医学模式转变。
Abstract	The increased resistance of Helicobacter pylori (H. pylori) has led to an increase in the failure rate of traditional empirical eradication therapy, and precise intervention strategies are urgently needed. This article systematically expounds the guiding value of resistance gene detection for personalized treatment, focusing on the association mechanism between 23S rRNA, gyrA, PBP1 and other gene mutations and clarithromycin, levofloxacin, and amoxicillin resistance phenotypes. Studies have shown that individualized programs based on genotype detection can significantly improve the eradication rate, which is more advantageous than traditional empirical therapy, while reducing the incidence of irrational use of antibiotics and related adverse reactions. The accurate identification of multidrug-resistant strains depends on the clinical application of technologies such as real-time fluorescence PCR and gene sequencing, and its rapidity and specificity provide technical guarantees for optimizing treatment plans. The study further pointed out that integrating regional resistance epidemiological data and establishing a standardized detection system are the key to improving the success rate of treatment, marking the transformation of Helicobacter pylori infection treatment to a precision medicine model.
关键词	幽门螺杆菌；耐药基因检测；个体化治疗；抗生素耐药性；精准医学
KeyWord	Helicobacter pylori; Drug resistance gene detection; Personalized treatment; Antibiotic resistance; Precision medicine
基金项目
页码	26-31

参考文献
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引用本文

张俊. 幽门螺杆菌耐药基因检测在个体化根除治疗中的价值 [J]. 国际内科前沿杂志. 2024; 5; (1). 26 - 31.

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