International Research in Chinese Medicine

Objective Based on the theory of pathogenic dampness, the clinical efficacy of modified Yiyi Fuzi Baijiang Powder in the treatment of mild to moderate ulcerative colitis was observed. Methods From September 2022 to November 2024,46 patients with mild to moderate ulcerative colitis were treated in Suzhou Hospital of Traditional Chinese Medicine and the Second Affiliated Hospital of Soochow University. According to the random number method, they were divided into two groups.23 patients in the control group were treated with mesalazine sustained-release granules orally, and 23 patients in the treatment group were treated with modified Yiyi Fuzi Baijiang powder (decoction) orally on the basis of the control group. The course of treatment in both groups was 12 weeks. The TCM syndrome score, disease activity index and histological score of intestinal mucosa under colonoscopy were compared between the two groups before and after treatment, and the clinical efficacy was analyzed. Results After 12 weeks of treatment, the scores of TCM syndromes, disease activity index and histological scores of intestinal mucosa under colonoscopy were improved in both groups, and the treatment group was better than the control group, the difference was statistically significant (P < 0.05). Conclusion Modified Yiyi Fuzi Baijiang Powder combined with mesalazine can effectively alleviate the clinical symptoms of patients with ulcerative colitis, reduce the inflammatory response, promote the healing of intestinal mucosa, and improve the quality of life. Therefore, the modified Yiyi Fuzi Baijiang powder (representative prescription) based on the ' Xintong Qinghua method ' is in line with the pathogenesis of UC.

Ulcerative colitis; Dampness; Xintong Qinghua method; Modified Yiyi Fuzi Baijiang Powder; Clinical efficacy