中药与现代合成药物联合应用的研究现状

Current research status of combined applications of traditional Chinese medicine and modern synthetic drugs

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DOI 10.12208/j.ircm.20250023
刊名
International Research in Chinese Medicine
年,卷(期) 2025, 5(2)
作者
作者单位

贵州中医药大学 贵州贵阳

摘要
中药与现代合成药物的联合应用已成为近年来医学研究与临床实践中的重要方向。中药以整体观念和辨证施治为核心,具有多成分、多靶点、多途径的综合调节作用,而现代合成药物则以明确的分子靶点和快速的药理反应见长。二者结合,不仅能够在疾病治疗中发挥协同增效的作用,还能够在一定程度上降低毒副反应,提高患者的依从性与生活质量。随着临床研究和实验研究的不断深入,联合用药在神经系统疾病、心血管疾病、肝胆疾病、呼吸系统疾病、免疫与代谢性疾病、妇科疾病以及肿瘤治疗等多个领域均显示出广阔的应用前景。与此同时,多组学技术、人工智能和大数据分析的引入,为揭示中药与合成药物的相互作用机制提供了新的研究路径。然而,联合应用仍面临药物相互作用机制复杂、有效性与安全性评价体系尚不完善、质量标准化不足以及法规监管等挑战。综上所述,中药与现代合成药物的联合应用具有显著的学术与临床价值,其未来发展需要依托循证医学研究、跨学科技术融合及国际化合作,以实现更高水平的个体化精准医疗。
Abstract
The combined application of traditional Chinese medicine (TCM) and modern synthetic drugs has become an important focus in recent medical research and clinical practice. TCM, characterized by holistic concepts and syndrome differentiation, exerts comprehensive regulatory effects through multi-component, multi-target, and multi-pathway mechanisms, while modern synthetic drugs are known for their clear molecular targets and rapid pharmacological responses. Their integration not only achieves synergistic therapeutic effects but also reduces adverse reactions, improves patient compliance, and enhances quality of life. With continuous progress in both clinical and experimental studies, combined therapy has shown promising outcomes in the treatment of neurological disorders, cardiovascular diseases, hepatobiliary conditions, respiratory diseases, immune and metabolic disorders, gynecological diseases, and cancers. Moreover, the application of multi-omics technologies, artificial intelligence, and big data analytics provides new approaches to elucidate the mechanisms underlying TCM–drug interactions. However, challenges remain, including the complexity of drug–drug interactions, incomplete evaluation systems for efficacy and safety, lack of standardization, and regulatory concerns. In summary, the combined use of TCM and modern synthetic drugs holds significant academic and clinical value. Future development requires support from evidence-based medicine, interdisciplinary technological integration, and international collaboration, aiming to achieve a higher level of individualized and precision medicine.
关键词
中药;现代合成药物;联合应用;临床疗效;机制研究
KeyWord
Traditional Chinese medicine; Modern synthetic drugs; Combined application; Clinical efficacy; Mechanism research
基金项目
页码 44-54
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朱晨. 中药与现代合成药物联合应用的研究现状 [J]. 国际中医药研究. 2025; 5; (2). 44 - 54.

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